Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.
Identifieur interne : 003371 ( Main/Exploration ); précédent : 003370; suivant : 003372Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.
Auteurs : Olivia S. Gardner [États-Unis] ; Chung-Wai Shiau ; Ching-Shih Chen ; Lee M. GravesSource :
- The Journal of biological chemistry [ 0021-9258 ] ; 2005.
Descripteurs français
- KwdFr :
- Activation enzymatique (MeSH), Animaux (MeSH), Antinéoplasiques (pharmacologie), Benzylamines (métabolisme), Calcium-Calmodulin-Dependent Protein Kinase Type 2 (MeSH), Calcium-Calmodulin-Dependent Protein Kinases (métabolisme), Cellules cultivées (MeSH), Cellules épithéliales (cytologie), Chromanes (pharmacologie), Facteurs temps (MeSH), Foie (cytologie), Immunoprécipitation (MeSH), Immunotransfert (MeSH), Liaison aux protéines (MeSH), Ligands (MeSH), MAP Kinase Kinase 3 (métabolisme), MAP Kinase Kinase 6 (métabolisme), Milieux de culture sans sérum (pharmacologie), Modèles biologiques (MeSH), Modèles chimiques (MeSH), Phosphorylation (MeSH), Rats (MeSH), Récepteur PPAR gamma (métabolisme), Réticulum endoplasmique (métabolisme), Sulfonamides (métabolisme), Thiazolidinediones (métabolisme), Thiazolidinediones (pharmacologie), Transduction du signal (MeSH), Troglitazone (MeSH), eIF-2 Kinase (métabolisme), p38 Mitogen-Activated Protein Kinases (métabolisme), Électrophorèse sur gel de polyacrylamide (MeSH).
- MESH :
- cytologie : Cellules épithéliales, Foie.
- métabolisme : Benzylamines, Calcium-Calmodulin-Dependent Protein Kinases, MAP Kinase Kinase 3, MAP Kinase Kinase 6, Récepteur PPAR gamma, Réticulum endoplasmique, Sulfonamides, Thiazolidinediones, eIF-2 Kinase, p38 Mitogen-Activated Protein Kinases.
- pharmacologie : Antinéoplasiques, Chromanes, Milieux de culture sans sérum, Thiazolidinediones.
- Activation enzymatique, Animaux, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cellules cultivées, Facteurs temps, Immunoprécipitation, Immunotransfert, Liaison aux protéines, Ligands, Modèles biologiques, Modèles chimiques, Phosphorylation, Rats, Transduction du signal, Troglitazone, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Animals (MeSH), Antineoplastic Agents (pharmacology), Benzylamines (metabolism), Calcium-Calmodulin-Dependent Protein Kinase Type 2 (MeSH), Calcium-Calmodulin-Dependent Protein Kinases (metabolism), Cells, Cultured (MeSH), Chromans (pharmacology), Culture Media, Serum-Free (pharmacology), Electrophoresis, Polyacrylamide Gel (MeSH), Endoplasmic Reticulum (metabolism), Enzyme Activation (MeSH), Epithelial Cells (cytology), Immunoblotting (MeSH), Immunoprecipitation (MeSH), Ligands (MeSH), Liver (cytology), MAP Kinase Kinase 3 (metabolism), MAP Kinase Kinase 6 (metabolism), Models, Biological (MeSH), Models, Chemical (MeSH), PPAR gamma (metabolism), Phosphorylation (MeSH), Protein Binding (MeSH), Rats (MeSH), Signal Transduction (MeSH), Sulfonamides (metabolism), Thiazolidinediones (metabolism), Thiazolidinediones (pharmacology), Time Factors (MeSH), Troglitazone (MeSH), eIF-2 Kinase (metabolism), p38 Mitogen-Activated Protein Kinases (metabolism).
- MESH :
- chemical , metabolism : Benzylamines, Calcium-Calmodulin-Dependent Protein Kinases, MAP Kinase Kinase 3, MAP Kinase Kinase 6, PPAR gamma, Sulfonamides, Thiazolidinediones, eIF-2 Kinase, p38 Mitogen-Activated Protein Kinases.
- chemical , pharmacology : Antineoplastic Agents, Chromans, Culture Media, Serum-Free, Thiazolidinediones.
- cytology : Epithelial Cells, Liver.
- metabolism : Endoplasmic Reticulum.
- Animals, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cells, Cultured, Electrophoresis, Polyacrylamide Gel, Enzyme Activation, Immunoblotting, Immunoprecipitation, Ligands, Models, Biological, Models, Chemical, Phosphorylation, Protein Binding, Rats, Signal Transduction, Time Factors, Troglitazone.
Abstract
The thiazolidinediones (TZDs) are synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligands that promote increased insulin sensitivity in type II diabetic patients. In addition to their ability to improve glucose homeostasis, TZDs also exert anti-proliferative effects by a mechanism that is unclear. Our laboratory has shown that two TZDs, ciglitazone and troglitazone, rapidly induce calcium-dependent p38 mitogen-activated protein kinase (MAPK) phosphorylation in liver epithelial cells. Here, we further characterize the mechanism responsible for p38 MAPK activation by PPARgamma ligands and correlate this with the induction of endoplasmic reticulum (ER) stress. Specifically, we show that TZDs rapidly activate the ER stress-responsive pancreatic eukaryotic initiation factor 2alpha (eIF2alpha) kinase or PKR (double-stranded RNA-activated protein kinase)-like endoplasmic reticulum kinase/pancreatic eIF2alpha kinase, and that activation of these kinases is correlated with subsequent eIF2alpha phosphorylation. Interestingly, PPARgamma ligands not only activated calcium/calmodulin-dependent kinase II (CaMKII) 2-fold over control, but the selective CaMKII inhibitor, KN-93, attenuated MKK3/6 and p38 as well as PKR and eIF2alpha phosphorylation. Although CaMKII was not affected by inhibition of PKR with 2-aminopurine, phosphorylation of MKK3/6 and p38 as well as eIF2alpha were significantly reduced. Collectively, these data provide evidence that CaMKII is a regulator of PKR-dependent p38 and eIF2alpha phosphorylation in response to ER calcium depletion by TZDs. Furthermore, using structural derivatives of TZDs that lack PPARgamma ligand-binding activity as well as a PPARgamma antagonist, we show that activation of these kinase signaling pathways is PPARgamma-independent.
DOI: 10.1074/jbc.M410445200
PubMed: 15649892
Affiliations:
- États-Unis
- Caroline du Nord
- Chapel Hill (Caroline du Nord)
- Université de Caroline du Nord à Chapel Hill
Links toward previous steps (curation, corpus...)
Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Antineoplastic Agents (pharmacology)</term>
<term>Benzylamines (metabolism)</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Type 2 (MeSH)</term>
<term>Calcium-Calmodulin-Dependent Protein Kinases (metabolism)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Chromans (pharmacology)</term>
<term>Culture Media, Serum-Free (pharmacology)</term>
<term>Electrophoresis, Polyacrylamide Gel (MeSH)</term>
<term>Endoplasmic Reticulum (metabolism)</term>
<term>Enzyme Activation (MeSH)</term>
<term>Epithelial Cells (cytology)</term>
<term>Immunoblotting (MeSH)</term>
<term>Immunoprecipitation (MeSH)</term>
<term>Ligands (MeSH)</term>
<term>Liver (cytology)</term>
<term>MAP Kinase Kinase 3 (metabolism)</term>
<term>MAP Kinase Kinase 6 (metabolism)</term>
<term>Models, Biological (MeSH)</term>
<term>Models, Chemical (MeSH)</term>
<term>PPAR gamma (metabolism)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protein Binding (MeSH)</term>
<term>Rats (MeSH)</term>
<term>Signal Transduction (MeSH)</term>
<term>Sulfonamides (metabolism)</term>
<term>Thiazolidinediones (metabolism)</term>
<term>Thiazolidinediones (pharmacology)</term>
<term>Time Factors (MeSH)</term>
<term>Troglitazone (MeSH)</term>
<term>eIF-2 Kinase (metabolism)</term>
<term>p38 Mitogen-Activated Protein Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation enzymatique (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Antinéoplasiques (pharmacologie)</term>
<term>Benzylamines (métabolisme)</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Type 2 (MeSH)</term>
<term>Calcium-Calmodulin-Dependent Protein Kinases (métabolisme)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Cellules épithéliales (cytologie)</term>
<term>Chromanes (pharmacologie)</term>
<term>Facteurs temps (MeSH)</term>
<term>Foie (cytologie)</term>
<term>Immunoprécipitation (MeSH)</term>
<term>Immunotransfert (MeSH)</term>
<term>Liaison aux protéines (MeSH)</term>
<term>Ligands (MeSH)</term>
<term>MAP Kinase Kinase 3 (métabolisme)</term>
<term>MAP Kinase Kinase 6 (métabolisme)</term>
<term>Milieux de culture sans sérum (pharmacologie)</term>
<term>Modèles biologiques (MeSH)</term>
<term>Modèles chimiques (MeSH)</term>
<term>Phosphorylation (MeSH)</term>
<term>Rats (MeSH)</term>
<term>Récepteur PPAR gamma (métabolisme)</term>
<term>Réticulum endoplasmique (métabolisme)</term>
<term>Sulfonamides (métabolisme)</term>
<term>Thiazolidinediones (métabolisme)</term>
<term>Thiazolidinediones (pharmacologie)</term>
<term>Transduction du signal (MeSH)</term>
<term>Troglitazone (MeSH)</term>
<term>eIF-2 Kinase (métabolisme)</term>
<term>p38 Mitogen-Activated Protein Kinases (métabolisme)</term>
<term>Électrophorèse sur gel de polyacrylamide (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Benzylamines</term>
<term>Calcium-Calmodulin-Dependent Protein Kinases</term>
<term>MAP Kinase Kinase 3</term>
<term>MAP Kinase Kinase 6</term>
<term>PPAR gamma</term>
<term>Sulfonamides</term>
<term>Thiazolidinediones</term>
<term>eIF-2 Kinase</term>
<term>p38 Mitogen-Activated Protein Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Chromans</term>
<term>Culture Media, Serum-Free</term>
<term>Thiazolidinediones</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Foie</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Epithelial Cells</term>
<term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endoplasmic Reticulum</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Benzylamines</term>
<term>Calcium-Calmodulin-Dependent Protein Kinases</term>
<term>MAP Kinase Kinase 3</term>
<term>MAP Kinase Kinase 6</term>
<term>Récepteur PPAR gamma</term>
<term>Réticulum endoplasmique</term>
<term>Sulfonamides</term>
<term>Thiazolidinediones</term>
<term>eIF-2 Kinase</term>
<term>p38 Mitogen-Activated Protein Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Chromanes</term>
<term>Milieux de culture sans sérum</term>
<term>Thiazolidinediones</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Type 2</term>
<term>Cells, Cultured</term>
<term>Electrophoresis, Polyacrylamide Gel</term>
<term>Enzyme Activation</term>
<term>Immunoblotting</term>
<term>Immunoprecipitation</term>
<term>Ligands</term>
<term>Models, Biological</term>
<term>Models, Chemical</term>
<term>Phosphorylation</term>
<term>Protein Binding</term>
<term>Rats</term>
<term>Signal Transduction</term>
<term>Time Factors</term>
<term>Troglitazone</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term>
<term>Animaux</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Type 2</term>
<term>Cellules cultivées</term>
<term>Facteurs temps</term>
<term>Immunoprécipitation</term>
<term>Immunotransfert</term>
<term>Liaison aux protéines</term>
<term>Ligands</term>
<term>Modèles biologiques</term>
<term>Modèles chimiques</term>
<term>Phosphorylation</term>
<term>Rats</term>
<term>Transduction du signal</term>
<term>Troglitazone</term>
<term>Électrophorèse sur gel de polyacrylamide</term>
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<front><div type="abstract" xml:lang="en">The thiazolidinediones (TZDs) are synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligands that promote increased insulin sensitivity in type II diabetic patients. In addition to their ability to improve glucose homeostasis, TZDs also exert anti-proliferative effects by a mechanism that is unclear. Our laboratory has shown that two TZDs, ciglitazone and troglitazone, rapidly induce calcium-dependent p38 mitogen-activated protein kinase (MAPK) phosphorylation in liver epithelial cells. Here, we further characterize the mechanism responsible for p38 MAPK activation by PPARgamma ligands and correlate this with the induction of endoplasmic reticulum (ER) stress. Specifically, we show that TZDs rapidly activate the ER stress-responsive pancreatic eukaryotic initiation factor 2alpha (eIF2alpha) kinase or PKR (double-stranded RNA-activated protein kinase)-like endoplasmic reticulum kinase/pancreatic eIF2alpha kinase, and that activation of these kinases is correlated with subsequent eIF2alpha phosphorylation. Interestingly, PPARgamma ligands not only activated calcium/calmodulin-dependent kinase II (CaMKII) 2-fold over control, but the selective CaMKII inhibitor, KN-93, attenuated MKK3/6 and p38 as well as PKR and eIF2alpha phosphorylation. Although CaMKII was not affected by inhibition of PKR with 2-aminopurine, phosphorylation of MKK3/6 and p38 as well as eIF2alpha were significantly reduced. Collectively, these data provide evidence that CaMKII is a regulator of PKR-dependent p38 and eIF2alpha phosphorylation in response to ER calcium depletion by TZDs. Furthermore, using structural derivatives of TZDs that lack PPARgamma ligand-binding activity as well as a PPARgamma antagonist, we show that activation of these kinase signaling pathways is PPARgamma-independent.</div>
</front>
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<DateCompleted><Year>2005</Year>
<Month>04</Month>
<Day>25</Day>
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<ArticleTitle>Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.</ArticleTitle>
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<Abstract><AbstractText>The thiazolidinediones (TZDs) are synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligands that promote increased insulin sensitivity in type II diabetic patients. In addition to their ability to improve glucose homeostasis, TZDs also exert anti-proliferative effects by a mechanism that is unclear. Our laboratory has shown that two TZDs, ciglitazone and troglitazone, rapidly induce calcium-dependent p38 mitogen-activated protein kinase (MAPK) phosphorylation in liver epithelial cells. Here, we further characterize the mechanism responsible for p38 MAPK activation by PPARgamma ligands and correlate this with the induction of endoplasmic reticulum (ER) stress. Specifically, we show that TZDs rapidly activate the ER stress-responsive pancreatic eukaryotic initiation factor 2alpha (eIF2alpha) kinase or PKR (double-stranded RNA-activated protein kinase)-like endoplasmic reticulum kinase/pancreatic eIF2alpha kinase, and that activation of these kinases is correlated with subsequent eIF2alpha phosphorylation. Interestingly, PPARgamma ligands not only activated calcium/calmodulin-dependent kinase II (CaMKII) 2-fold over control, but the selective CaMKII inhibitor, KN-93, attenuated MKK3/6 and p38 as well as PKR and eIF2alpha phosphorylation. Although CaMKII was not affected by inhibition of PKR with 2-aminopurine, phosphorylation of MKK3/6 and p38 as well as eIF2alpha were significantly reduced. Collectively, these data provide evidence that CaMKII is a regulator of PKR-dependent p38 and eIF2alpha phosphorylation in response to ER calcium depletion by TZDs. Furthermore, using structural derivatives of TZDs that lack PPARgamma ligand-binding activity as well as a PPARgamma antagonist, we show that activation of these kinase signaling pathways is PPARgamma-independent.</AbstractText>
</Abstract>
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<ForeName>Lee M</ForeName>
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<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>1</Month>
<Day>15</Day>
<Hour>9</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2005</Year>
<Month>4</Month>
<Day>26</Day>
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<ArticleIdList><ArticleId IdType="pubmed">15649892</ArticleId>
<ArticleId IdType="pii">M410445200</ArticleId>
<ArticleId IdType="doi">10.1074/jbc.M410445200</ArticleId>
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<affiliations><list><country><li>États-Unis</li>
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<region><li>Caroline du Nord</li>
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<settlement><li>Chapel Hill (Caroline du Nord)</li>
</settlement>
<orgName><li>Université de Caroline du Nord à Chapel Hill</li>
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<tree><noCountry><name sortKey="Chen, Ching Shih" sort="Chen, Ching Shih" uniqKey="Chen C" first="Ching-Shih" last="Chen">Ching-Shih Chen</name>
<name sortKey="Graves, Lee M" sort="Graves, Lee M" uniqKey="Graves L" first="Lee M" last="Graves">Lee M. Graves</name>
<name sortKey="Shiau, Chung Wai" sort="Shiau, Chung Wai" uniqKey="Shiau C" first="Chung-Wai" last="Shiau">Chung-Wai Shiau</name>
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<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Gardner, Olivia S" sort="Gardner, Olivia S" uniqKey="Gardner O" first="Olivia S" last="Gardner">Olivia S. Gardner</name>
</region>
</country>
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